Omega-3 Fatty Acids: How to Maximize Their Benefits

Among all fatty acids, the polyunsaturated omega-3 fatty acids—EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid)—are especially valuable for health. They support the heart, blood vessels, and brain, help regulate inflammation, and contribute to a balanced metabolism. Omega-3s are also key components of cell membranes, particularly in nerve tissue and the heart, ensuring flexibility and proper function.

However, omega-3 fatty acids contain multiple double bonds in their molecular structure, making them chemically unstable and prone to oxidation. Exposure to oxygen, light, or heat can trigger oxidation, leading to the formation of free radicals and lipid peroxidation products. Once oxidized, omega-3s lose much of their beneficial potential and may even promote inflammation and cellular damage.

 

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Antioxidants—compounds that neutralize free radicals and reduce oxidative stress—play an important role in preventing this unwanted oxidation. When consumed together with omega-3s, antioxidants help preserve fatty acids, maintaining their bioavailability and effectiveness. It is therefore beneficial to combine foods rich in omega-3 (such as fatty fish and flaxseed oil) with foods high in antioxidants (such as berries, nuts, and leafy greens).

Key Antioxidants That Protect Omega-3 Fatty Acids

Vitamin E (tocopherols and tocotrienols)

The most common and well-studied antioxidant for protecting omega-3s.

Fat-soluble and concentrated in cell membranes and fat stores, where lipid oxidation occurs.

Prevents chain reactions of lipid peroxidation by stabilizing omega-3s.

Vitamin C (ascorbic acid)

A water-soluble antioxidant that can regenerate oxidized vitamin E, restoring it to its active form.

Works synergistically with vitamin E, enhancing overall antioxidant defense.

Recommended to be taken together with vitamin E and omega-3s.

Selenium

A trace element essential for glutathione peroxidase enzymes, which neutralize lipid peroxides.

Supports other antioxidant systems and prevents the accumulation of harmful peroxidation products.

Polyphenols

Natural antioxidants found in plants (e.g., curcumin, wild berry extracts).

Provide strong antioxidant and anti-inflammatory effects.

Carotenoids (e.g., astaxanthin, beta-carotene, lycopene)

Fat-soluble antioxidants that neutralize free radicals and protect lipids from oxidation.

Combining Antioxidants for Greater Effect

 

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For comprehensive antioxidant protection, many natural dietary supplements combine antioxidants from different classes into one formulation. A good example is the natural supplement Sanatur Astaxanthin Plus, developed according to the “multi-colored” principle. It contains three plant-based pigments, each targeting different types of free radicals:

Red: Astaxanthin, the most powerful carotenoid antioxidant.

Yellow: Organic mustard powder, a natural source of selenium.

Blue: Organic blueberry powder, rich in polyphenols.